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Navigating cold agglutinin-induced hemolytic anemia in developing countries: A case report and literature review.
SAGE Open Med Case Rep
September 2024
Memon Medical Institute Hospital, Karachi, Pakistan.
Article Synopsis
- Cold agglutinin-induced hemolytic anemia poses diagnostic challenges, especially in resource-limited settings like Pakistan, highlighted by a case of a 92-year-old male with severe anemia and altered consciousness.
- Diagnosis was confirmed through positive Direct Coombs test and elevated cold agglutinin titers, demonstrating the importance of specific lab findings in identifying the condition.
- Multidisciplinary management, including blood transfusions and immunosuppressive therapy, resolved the patient's symptoms, underscoring the need for enhanced clinician awareness and timely interventions for better patient outcomes.
IgA plasma cell myeloma presenting as cold agglutinin-induced haemolytic transfusion reaction.
BMJ Case Rep
February 2024
Department of the Pathology, George Washington University Medical Faculty Associates, Washington, District of Columbia, USA
Cold agglutinins produced in the setting of B cell neoplasms, such as lymphoplasmacytic lymphoma and plasma cell myeloma, can mediate autoimmune haemolytic anemia. Transfusion of these patients can exacerbate cold agglutinin-mediated haemolysis. Moreover, the workup for these reactions represents a diagnostic challenge due in part to false negative direct antiglobulin tests (DATs).
View Article and Find Full Text PDFCold agglutinin-induced acrocyanosis without hemolytic anemia.
Ann Hematol
February 2024
Department of Respiratory Medicine, National Hospital Organization Iwakuni Clinical Center, 1-1-1, Atago-Cho, Iwakuni, 740-8510, Japan.
Dual arterial thrombosis: A diagnostic enigma.
Ann Afr Med
October 2022
Department of Neurology, JSS Medical College, Mysore, Karnataka, India.
Cold agglutinin disease is a rare cause of arterial thrombosis leading to stroke, commonly encountered against a background of mycoplasma pneumonia infections. A 22-year-old patient presented with acute-onset left hemiplegia preceded by a short history of fever and cough. Magnetic resonance imaging (MRI) showed a right middle cerebral artery infarct.
View Article and Find Full Text PDFCold agglutinin-induced hemolytic anemia during room temperature fluid resuscitation: a case report.
J Med Case Rep
April 2021
Niigata City General Hospital Emergency & Critical Care Medicine, 463-7 Shumoku, Chuo-ku, Niigata, 950-1197, Japan.
Background: Cold agglutinin disease can cause the agglutination of red blood cells and hemolytic anemia due to cold temperature. Herein, we report a case of progressive hemolytic anemia due to cold agglutinin disease during fluid resuscitation and in the absence of exposure to cold.
Case Presentation: A 71-year-old Japanese man was admitted to the emergency department with signs of hypotension and disturbed consciousness.
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