Background And Objective: Generally, protection against SARS-CoV-2 was assessed by the measurement of antibody titers against spike protein and receptor binding domain "RBD". Many global efforts lead to development of several vaccines based on various strategies. The aim of the present study was to evaluate the efficacy of Sputnik V vaccine among Sari healthcare staff population, Iran.
Methods: Seventy-nine health professional staffs that were vaccinated with two doses of Sputnik V vaccine were selected. The Immune response against spike and RBD proteins was evaluated by ELISA assays 3-4 weeks after second dose of vaccine injection.
Results: The results showed the antibody titers were raised after vaccination. Data analysis has also demonstrated that the efficacy of vaccine was not related to age, gender and previous infection of SARS-CoV-2.
Conclusion: Sputnik V vaccine can lead to a protective response against COVID-19 infection in high percentage of the population. J. Med. Invest. 70 : 317-320, August, 2023.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.2152/jmi.70.317 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Receptor Binding Domain-Specific B Cell Memory Responses Among Individuals Vaccinated Against SARS-CoV-2.
Vaccines (Basel)
December 2024
BRIC-Translational Health Science and Technology Institute, Faridabad 21001, India.
: The COVID-19 pandemic prompted unprecedented vaccine development efforts against SARS-CoV-2. India, which was one of the countries most impacted by COVID-19, developed its indigenous vaccine in addition to utilizing the ones developed by other countries. While antibody levels and neutralizing antibody titres are considered initial correlates of immune protection, long-term protection from the pathogen relies on memory B and T cells and their recall responses.
View Article and Find Full Text PDFAntibody Avidity Maturation Following Booster Vaccination with an Intranasal Adenovirus Salnavac Vaccine.
Vaccines (Basel)
December 2024
Laboratory of Immunochemistry, National Research Center Institute of Immunology, Federal Medical Biological Agency of Russia, 115522 Moscow, Russia.
Background: The COVID-19 pandemic has led to the rapid development of new vaccines and methods of testing vaccine-induced immunity. Despite the extensive research that has been conducted on the level of specific antibodies, less attention has been paid to studying the avidity of these antibodies. The avidity of serum antibodies is associated with a vaccine showing high effectiveness and reflects the process of affinity maturation.
View Article and Find Full Text PDFEffect of Homologous and Heterologous Booster in COVID-19 Vaccination.
Pharmaceuticals (Basel)
December 2024
Institute for Biocides and Medical Ecology, Trebevićka 16, 11030 Belgrade, Serbia.
COVID-19 became a global health crisis in early 2020, and the way out of the crisis was the rapid development of vaccines by Sinopharm, Pfizer, and Sputnik, among others, which played a crucial role in controlling the pandemic. Therefore, this study aims to investigate the long-term immune response by measuring the levels of anti-S1 IgG antibodies induced by homologous and heterologous vaccination regimens. We investigated the titer of the anti-S1 IgG antibody produced for the viral surface antigen 3, 6 months after the second dose, before the third dose, and 1, 3, and 6 months after the third dose.
View Article and Find Full Text PDFImmunogenicity and Protectivity of Sputnik V Vaccine in hACE2-Transgenic Mice against Homologous and Heterologous SARS-CoV-2 Lineages Including Far-Distanced Omicron BA.5.
Vaccines (Basel)
October 2024
Federal State Budget Institution "National Research Centre for Epidemiology and Microbiology Named after Honorary Academician N F Gamaleya", Ministry of Health, Russian Federation, 123098 Moscow, Russia.
Article Synopsis
- The SARS-CoV-2 virus mutates continuously, leading to new variants like Omicron, which has reduced the effectiveness of vaccines worldwide.
- The study evaluated the Sputnik V vaccine's effectiveness against several SARS-CoV-2 variants using various research methods on transgenic mice.
- Results showed that while Sputnik V generates a strong immune response, its efficacy is significantly lower against the Omicron variant, highlighting the need for ongoing monitoring and potential development of new vaccines.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!