When bone is limited, short, ultra-short, or narrow implants help to restore oral rehabilitation with an acceptable long-term outcome. This becomes more difficult with severe vertical bone loss. Guided bone regeneration, onlay block transplantation, or sandwich osteotomy have been established to build up these defects. The alternative to the alveolar distraction osteogenesis (ADO) has only been established in some centers, with a standardized protocol. On the one hand, ADO is a biological procedure that allows almost a "restitutio ad integrum" when building up hard and soft tissue. On the other hand, there are clear indications, limitations, and complications of the procedure in the literature. In addition to the literature, concept of Tissue Regeneration by Alveolar Callusdistraction Cologne (TRACC), which has been practiced successfully for over two decades, will be presented for different indications.
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Article Synopsis
- The prolonged use of external fixation during distraction osteogenesis (DO) can heighten complications, while bone marrow mesenchymal stem cells (BMSCs) play a crucial role in bone regeneration due to their pro-angiogenic and osteogenic abilities.
- RSC-96, a type of Schwann cell, has been shown to promote the proliferation, migration, and differentiation of BMSCs when co-cultured, enhancing both bone formation and blood vessel development through neurotrophic factor secretion and activation of specific signaling pathways.
- In a rat DO model, RSC-96's conditioned medium improved bone healing outcomes, with notable increases in gene expression markers for osteogenesis and angiogenesis, alongside positive radiological and biomechanical assessments.
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