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The mitochondrial signature of cultured endothelial cells in sepsis: Identifying potential targets for treatment. | LitMetric

The mitochondrial signature of cultured endothelial cells in sepsis: Identifying potential targets for treatment.

Biochim Biophys Acta Mol Basis Dis

Unit of Excellence, Institute of Biomedicine and Molecular Genetics (IBGM), University of Valladolid and Spanish National Research Council (CSIC), Valladolid, Spain; Department of Cell Biology, Genetics, Histology and Pharmacology, University of Valladolid, Valladolid, Spain.

Published: February 2024

AI Article Synopsis

Article Abstract

Sepsis is the most common cause of death from infection in the world. Unfortunately, there is no specific treatment for patients with sepsis, and management relies on infection control and support of organ function. A better understanding of the underlying pathophysiology of this syndrome will help to develop innovative therapies. In this regard, it has been widely reported that endothelial cell activation and dysfunction are major contributors to the development of sepsis. This review aims to provide a comprehensive overview of emerging findings highlighting the prominent role of mitochondria in the endothelial response in in vitro experimental models of sepsis. Additionally, we discuss potential mitochondrial targets that have demonstrated protective effects in preclinical investigations against sepsis. These promising findings hold the potential to pave the way for future clinical trials in the field.

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Source
http://dx.doi.org/10.1016/j.bbadis.2023.166946DOI Listing

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