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Acrodermatitis dysmetabolica: lessons from two pediatric cases.
J Pediatr Endocrinol Metab
January 2025
Department of Pediatrics, Konya City Hospital, University of Health Sciences, Konya, Türkiye.
Objectives: Acrodermatitis dysmetabolica (AD) is a dermatologic manifestation associated with inherited metabolic disorders (IMDs), distinct from acrodermatitis enteropathica, which occurs solely due to zinc deficiency.
Case Presentation: This report presents two pediatric cases: a 30-month-old girl with maple syrup urine disease (MSUD) experiencing AD secondary to severe isoleucine deficiency due to a protein-restricted diet, showing improvement with dietary adjustments, and a 2.5-month-old boy infant with propionic acidemia (PA) who developed AD alongside septic shock, which progressed despite intervention.
Research progress on the molecular structure, function, and application in tumor therapy of zinc transporter ZIP4.
Int J Biol Sci
December 2024
Zhejiang University School of Medicine, Hangzhou, 310058, China.
ZIP4, a pivotal member of the ZIP family, is the causative gene for the hereditary disorder AE (acrodermatitis enteropathica) in humans, and plays an essential role in regulating zinc ion balance within cells. While research on the molecular structure of ZIP4 continues, there remains a lack of full understanding regarding the stereo-structural conformation of ZIP4 molecules. Currently, there are two hypotheses concerning the transport of zinc ions into the cytoplasm by ZIP4, with some contradictions between experimental studies.
View Article and Find Full Text PDFZinc Supplementation for Acrodermatitis Enteropathica Overlapped with Psoriasiform Lesions.
Psoriasis (Auckl)
November 2024
Department of Dermatology, Naval Medical Centre, Naval Medical University, Shanghai, 200052, People's Republic of China.
Acrodermatitis enteropathica (AE) can be caused by inherited or acquired zinc deficiency, among which site-specific skin lesions or even psoriasiform skin manifestations are present. Few cases exist in the literature involving the diagnosis and treatment of AE overlapped with psoriasiform lesions. In this case, we reported a teenage boy presented characteristic site-specific skin lesions of AE with low serum zinc level, subsequently progressed into generalized pustular psoriasiform manifestations under a genetic background, while a rapid recovery was observed after monotherapy of zinc supplementation.
View Article and Find Full Text PDFAcrodermatitis Enteropathica: A Case Report Involving a Delayed Diagnosis.
Cureus
October 2024
Department of Dermatology, King Abdulaziz Hospital, Makkah, SAU.
Article Synopsis
- A two-year-old girl experienced misdiagnoses such as tinea corporis and psoriasis, leading to ineffective treatments until a proper evaluation revealed her low zinc levels.
- After being diagnosed with AE, she was treated with zinc sulfate, resulting in the complete resolution of her skin lesions within two weeks.
Presentation of a Rare Case of Skin Signs Consistent With Scurvy and Acrodermatitis Enteropathica in the Context of Enolism With Multiple Nutritional Deficiencies.
Actas Dermosifiliogr
October 2024
Division of Dermatology, Department of Internal Medicine, Faculty of Medicine, Saga University, Saga, Japan. Electronic address:
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