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Plant cross-fertilization for production of dual-specific antibodies targeting both Ebola virus-like particles and HER2 protein in F plants.
Genes Genomics
January 2025
Department of Medicine, BioSystems Design Lab, College of Medicine, Chung-Ang University, 84 Heukseok-ro, Dongjak-gu, Seoul, 06974, Korea.
Background: This study explores the cross-fertilization of transgenic tobacco plants to produce dual-specific monoclonal antibodies (mAbs) targeting Ebola virus-like particles and HER2 proteins. We generated F plants by hybridizing individual transgenic lines expressing the anti-HER2 breast cancer VHH mAb (HV) and the H-13F6 human anti-Ebola large single chain mAb (EL).
Objective: Hybridizing transgenic plants to express dual-antibodies between different structures VHH and LSCK indicate the potential of transgenic plants as a cost-effective and scalable production system for dual targeting mAbs.
Exploiting CotA laccase from Antarctic Bacillus sp. PAMC28748 for efficient mediator-assisted dye decolorization and ABTS regeneration.
Chemosphere
January 2025
Department of Life Science and Biochemical Engineering, Graduate School, SunMoon University, Asan, 31460, Republic of Korea; Genome-based Bio-IT Convergence Institute, Asan, 31460, Republic of Korea; Bio Big Data-based Chungnam Smart Clean Research Leader Training Program, SunMoon University, Asan, 31460, Republic of Korea; Department of Pharmaceutical Engineering and Biotechnology, SunMoon University, Asan, 31460, Republic of Korea. Electronic address:
Laccases are of particular interest in addressing environmental challenges, such as the degradation of triphenylmethane (TPM) dyes, including crystal violet (CV) and Coomassie Brilliant Blue (CBB), which are commonly used in SDS-PAGE for protein visualization. However, these dyes present significant environmental concerns due to their resistance to degradation, which makes their removal from industrial wastewater a major challenge. To address this, the current study investigates the potential of a novel CotA laccase derived from Bacillus sp.
View Article and Find Full Text PDFEnhancing sulfide mitigation via the synergistic dosing of calcium peroxide and ferrous ions in gravity sewers: Efficiency and mechanism.
J Hazard Mater
January 2025
School of Environmental and Municipal Engineering, Xi'an University of Architecture and Technology, Xi'an 710055, China; Key Laboratory of Northwest Water Resources, Environment, and Ecology, Ministry of Education, Xi'an 710055, China. Electronic address:
Chemical dosing constitutes an effective strategy for sulfide control in sewers; however, its efficacy requires further optimization and enhancement. In this study, a novel dosing strategy using the synergistic dosing of calcium peroxide (CaO) and ferrous ions (Fe) for sulfide control was proposed, and its efficacy in controlling sulfides was evaluated using a long-term laboratory-scale reactor. The results showed that adding CaO-Fe improves the effect of sulfide control.
View Article and Find Full Text PDFMultilevel gene expression changes in lineages containing adaptive copy number variants.
Mol Biol Evol
January 2025
Center for Genomics and Systems Biology, Department of Biology, New York University.
Copy-number variants (CNVs) are an important class of genetic variation that can mediate rapid adaptive evolution. Whereas CNVs can increase the relative fitness of the organism, they can also incur a cost due to the associated increased gene expression and repetitive DNA. We previously evolved populations of Saccharomyces cerevisiae over hundreds of generations in glutamine-limited (Gln-) chemostats and observed the recurrent evolution of CNVs at the GAP1 locus.
View Article and Find Full Text PDFModeling Biases from Low-Pass Genome Sequencing to Enable Accurate Population Genetic Inferences.
Mol Biol Evol
January 2025
Department of Molecular and Cellular Biology, University of Arizona, Tucson, AZ 85721, USA.
Low-pass genome sequencing is cost-effective and enables analysis of large cohorts. However, it introduces biases by reducing heterozygous genotypes and low-frequency alleles, impacting subsequent analyses such as model-based demographic history inference. Several approaches exist for inferring an unbiased allele frequency spectrum (AFS) from low-pass data, but they can introduce spurious noise into the AFS.
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