AI Article Synopsis
- The study shows how humanized ACE2 interacts with a pseudovirus that has Spike proteins, highlighting the importance of type 2 innate lymphoid cells in the early stages of viral infection.
- These results are crucial for creating mucosal vaccines, which target infection prevention right at the entry points of the virus.
- This research also suggests potential new treatment methods for managing COVID-19 both before and after infection.
Article Abstract
Our study revealed the spatial interaction between humanized ACE2 and pseudovirus expressing Spike, emphasizing the role of type 2 innate lymphoid cells during the initial phase of viral infection. These findings provide a foundation for the development of mucosal vaccines and other treatment approaches for both pre- and post-infection management of coronavirus disease 2019.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10714800 | PMC |
| http://dx.doi.org/10.1128/spectrum.00878-23 | DOI Listing |
Publication Analysis
Top Keywords
spatiotemporal observations
4
observations host-pathogen
4
host-pathogen interactions
4
interactions mucosa
4
mucosa sars-cov-2
4
sars-cov-2 infection
4
infection indicate
4
indicate protective
4
protective role
4
role ilc2s
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!