AI Article Synopsis
- A variety of diseases can be caused by a specific organism, including mild skin infections and severe conditions like pneumonia and sepsis.
- The organism attacks mucosal and skin barriers, triggering harmful inflammation by promoting the release of chemokines from epithelial cells.
- Researchers have cloned and characterized a new secreted protein that mainly functions to stimulate chemokine production, potentially aiding the organism in penetrating host defenses.
Article Abstract
causes a myriad of human diseases, ranging from relatively mild soft tissue infections to highly fatal pneumonia, sepsis, and toxic shock syndrome. The organisms primarily cause diseases across mucosal and skin barriers. In order to facilitate penetration of barriers, causes harmful inflammation by inducing chemokines from epithelial cells. We report the cloning and characterization of a novel secreted protein that induces chemokine production from epithelial cells as its major demonstrable function. This secreted protein possibly helps and its secreted proteins to penetrate host barriers.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10715055 | PMC |
| http://dx.doi.org/10.1128/spectrum.02898-23 | DOI Listing |
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