AI Article Synopsis
- The increasing rates of allergies and autoimmune diseases in developed countries highlight the need to understand how gut microbiota affects the immune system.
- Changes to the gut microbiota during the crucial early life stage can significantly impact immune development and function.
- This review examines recent findings on the relationship between early-life microbiota and immune health, and explores potential treatments to correct imbalances in gut bacteria during this vulnerable period.
Article Abstract
As the prevalence of allergy and autoimmune disease in industrialized societies continues to rise, improving our understanding of the mechanistic roles behind microbiota-immune homeostasis has become critical for informing therapeutic interventions in cases of dysbiosis. Of particular importance, are alterations to intestinal microbiota occurring within the critical neonatal window, during which the immune system is highly vulnerable to environmental exposures. This review will highlight recent literature concerning mechanisms of early-life microbiota-immune homeostasis as well as discuss the potential for therapeutics in restoring dysbiosis in early life.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10627000 | PMC |
| http://dx.doi.org/10.3389/fimmu.2023.1266876 | DOI Listing |
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