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Cutaneous ulceration in juvenile dermatomyositis with anti-melanoma differentiation-associated gene 5. | LitMetric

Cutaneous ulceration in juvenile dermatomyositis with anti-melanoma differentiation-associated gene 5.

Pediatr Dermatol

Department of Nephrology, Rheumatology and Immunology, Shanghai Children's Hospital, School of medicine, Shanghai Jiao Tong University, Shanghai, China.

Published: March 2024

This report presents the case of an 11-year-old girl with juvenile dermatomyositis (JDM), anti-MDA5 antibodies and multiple skin ulcers. Treatment with traditional immunomodulators and tofacitinib resulted in healing of the skin ulcers and normalization of muscle enzyme markers. This case highlights the significance of recognizing the association between anti-MDA5 antibodies and cutaneous ulceration in JDM and supports the use of Janus kinase inhibitors as a management option.

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Source
http://dx.doi.org/10.1111/pde.15469DOI Listing

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