Objective: To evaluate the association between patients' characteristics and disease activity in an Argentine lupus registry.
Methods: Cross-sectional study. Disease activity was stratified into: Remission off-treatment: SLEDAI = 0, without prednisone and immunosuppressive drugs. Low disease activity Toronto Cohort (LDA-TC): SLEDAI ≤2, without prednisone or immunosuppressive drugs. Modified lupus low disease activity (mLLDAS): SLEDAI score of ≤4, with no activity in major organ systems and no new features, prednisone of ≤10 mg/day and/or immunosuppressive drugs (maintenance dose) and Active disease: SLEDAI score of >4 and prednisone >10 mg/day and immunosuppressive drugs. A descriptive analysis and logistic regression model were performed.
Results: A total of 1346 patients were included. Of them, 1.6% achieved remission off steroids, 0.8% LDA-TC, 12.1% mLLDAS and the remaining 85.4% had active disease. Active disease was associated with younger age ( ≤ 0.001), a shorter time to diagnosis ( ≤ 0.001), higher frequency of hospitalizations ( ≤ 0.001), seizures ( = 0.022), serosal disease ( ≤ 0.001), nephritis ( ≤ 0.001), higher SDI ( ≤ 0.001), greater use of immunosuppressive therapies and higher doses of prednisone compared to those on mLLDAS. In the multivariable analysis, the variables associated with active disease were the presence of pleuritis (OR 2.1, 95% CI 1.2-3.9; = 0.007), persistent proteinuria (OR 2.5, 95% CI 1.2-5.5; ≤ 0.011), nephritis (OR 2.5, 95% CI 1.2-5.6; = .018) and hospitalizations (OR 8.9, 95% CI 5.3-16.0; ≤ 0.001) whereas age at entry into the registry was negatively associated with it (OR 0.9, 95% CI 0.9-1.0; = 0.029).
Conclusion: Active disease was associated with shorter time to diagnosis, worse outcomes (SDI and hospitalizations) and renal, neurological and serosal disease.
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http://dx.doi.org/10.1177/09612033231209601 | DOI Listing |
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