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Classifying tumour infiltrating lymphocytes in oral squamous cell carcinoma histopathology using joint learning framework.
Sci Rep
January 2025
Electrical and Computer Engineering Department, University of Memphis, Memphis, TN, 38152, USA.
Oral squamous cell carcinoma (OSCC) is the most common form of oral cancer, with increasing global incidence and have poor prognosis. Tumour-infiltrating lymphocytes (TILs) are recognized as a key prognostic indicator and play a vital role in OSCC grading. However, current methods for TILs quantification are based on subjective visual assessments, leading to inter-observer variability and inconsistent diagnostic reproducibility.
View Article and Find Full Text PDFApplying implementation science frameworks to understand why fisherfolk continue or discontinue pre-exposure prophylaxis for HIV prevention in Uganda: a qualitative analysis.
BMJ Glob Health
January 2025
School of Public Health, Makerere University, Kampala, Uganda.
Introduction: In Uganda, fisherfolk have an HIV prevalence between 15% and 40%, significantly higher than the national average of 5.5%. Pre-exposure prophylaxis (PrEP) is effective in preventing HIV but faces challenges in uptake and continuation among fisherfolk.
View Article and Find Full Text PDFLead-Grouped Multi-Stage Learning for Myocardial Infarction Localization.
Methods
January 2025
School of Design, Hunan University, Changsha, 410082, China. Electronic address:
The electrocardiogram (ECG) is a ubiquitous medical diagnostic tool employed to localize myocardial infarction (MI) that is characterized by abnormal waveform patterns on the ECG. MI is a serious cardiovascular disease, and accurate, timely diagnosis is crucial for preventing severe outcomes. Current ECG analysis methods mainly rely on intra- and inter-lead feature extraction, but most models overlook the medical knowledge relevant to disease diagnosis.
View Article and Find Full Text PDFAnalysis of Acute Cerebrovascular Accidents following Cardiovascular Surgical Procedures: A Comprehensive 17-year study involving 24,412 patients at a leading Tertiary care institution in the United Kingdom.
Ann Vasc Surg
January 2025
Barts Heart Centre, St. Bartholomew's Hospital, London, UK; Neurovascular Research Laboratory, Faculty of Life Sciences and Education, University of South Wales, Glamorgan, UK; William Harvey Research Institute, Queen Mary University of London, London, UK.
Objective: The primary objective of this study is to quantify the incidence of stroke following cardiac surgery over 17 years at our centre. Additionally, we evaluated the potential risk factors leading to postoperative stroke in these patients.
Methods: Patient characteristics and perioperative data were collected for 24,412 patients undergoing surgery at our centre between January 2005 and December 2021.
Evaluation of Tele-Education in Malawi for Detection of Macular Features Using Optical Coherence Tomography.
Klin Monbl Augenheilkd
January 2025
Department of Ophthalmology, University Hospital Tübingen, Germany.
Purpose: The study aimed to assess the reliability of tele-education in training a Malawian ophthalmology resident to interpret optical coherence tomography (OCT) images of patients with macular conditions.
Methods: This was a retrospective analysis of 1000 macula-centered OCT image series from 1000 eyes of 1000 consecutive patients from Malawi, which involved initial interpretation by a German retina specialist (observer 1) (T). Observer 1 then trained a Malawian resident (observer 2) via email, and observer 2 independently interpreted images at T, followed by face-to-face training in Malawi and reinterpretation at T and T (3-month intervals).
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