Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1093/eurheartj/ehad485 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Liver proteomics identifies a disconnect between proteins associated with de novo lipogenesis and triglyceride storage.
J Lipid Res
December 2024
School of Life and Environmental Sciences, Charles Perkins Centre, Faculty of Science, The University of Sydney, Sydney, NSW, Australia; Garvan Institute, Sydney, NSW, Australia. Electronic address:
De novo lipogenesis (DNL) has been implicated in the development and progression of liver steatosis. Hepatic DNL is strongly influenced by dietary macronutrient composition with diets high in carbohydrate increasing DNL while diets high in fat decrease DNL. The enzymes in the core DNL pathway have been well characterized; however, less is known about other liver proteins that play accessory or regulatory roles.
View Article and Find Full Text PDFMurine HSD17β13 does not control liver steatosis and modestly impacts fibrosis in a sex- and diet-specific manner.
J Lipid Res
October 2024
Internal Medicine Research Unit, Pfizer Inc, Cambridge, Massachusetts, USA.
Human genetic studies show that loss of function mutations in 17-Beta hydroxysteroid dehydrogenase (HSD17β13) are associated with protection from non-alcoholic steatohepatitis (NASH). As a result, therapies that reduce HSD17β13 are being pursued for the treatment of NASH. However, inconsistent effects on steatosis, inflammation, and fibrosis pathogenesis have been reported in murine Hsd17b13 knockdown or knockout models.
View Article and Find Full Text PDFVitamin D/Bone Mineral Density and Triglyceride Paradoxes Seen in African Americans: A Cross-Sectional Study and Review of the Literature.
Int J Mol Sci
January 2024
Department of Pediatrics, Louisiana State University Health Sciences Center, 1501 Kings Highway, Shreveport, LA 71103, USA.
Vitamin D is known to have a positive effect on bone health. Despite the greater frequency of vitamin D deficiency in African Americans (AA), they have a higher bone mineral density (BMD) compared to whites, demonstrating a disconnect between BMD and vitamin D levels in AA. Another intriguing relationship seen in AA is the triglyceride (TG) paradox, an unusual phenomenon in which a normal TG status is observed even when patients house conditions known to be characterized by high TG levels, such as Type II diabetes.
View Article and Find Full Text PDFDisconnect between triglyceride reduction and cardiovascular outcomes: lessons from the PROMINENT and CLEAR Outcomes trials.
Eur Heart J
July 2024
IRCCS MultiMedica, via Milanese 300, 20099, Sesto San Giovanni, Milan, Italy.
Metabolic dysfunctions following chronic oral corticosterone are modified by adolescence and sex in mice.
Physiol Behav
October 2023
Departments of Psychology and Neuroscience and Behavior, Barnard College of Columbia University, New York, NY, 10027, United States. Electronic address:
Adolescence is a period of development in which shifts in responses to glucocorticoids is well-documented. Obesity and metabolic syndrome are substantial health issues whose rates continue to rise in both adult and adolescent populations. Though many interacting factors contribute to these dysfunctions, how these shifts in glucocorticoid responses may be related remain unknown.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!