AI Article Synopsis
- Noninvasive ventilation (NIV) is essential for preventing intubation in myasthenic crisis, but there is limited research on its long-term use in stable myasthenia gravis (MG) patients.
- A study analyzed 50 MG patients, finding 20% required long-term home NIV, particularly among those with more severe MG symptoms (grades IIB and IIIB).
- The research suggests that identifying MG severity can help predict which patients may need NIV, highlighting the prevalence of this intervention in stable individuals with generalized MG and bulbar or respiratory involvement.
Article Abstract
Background: Noninvasive ventilation (NIV) plays an important role in avoiding endotracheal intubation during myasthenic crisis, yet there are few published data concerning long-term home NIV in stable out-patients with myasthenia gravis (MG). The aim of this study was to describe the prevalence of NIV in a cohort of subjects with stable MG and to analyze contributing factors that could predict the need of NIV.
Methods: We performed a cross-sectional study that included subjects diagnosed with MG managed in the respiratory care unit over the previous year. Subjects underwent clinical analysis including demographic, clinical, and functional respiratory data.
Results: Of the 50 subjects included, 35 (70%) were positive for nicotinic acetylcholine receptor antibodies, and 68% had a diagnosis of generalized MG. Bulbar symptoms developed in 16 (32%), and 10 (20%) subjects needed long-term home NIV. The only variable predicting the need for long-term NIV was MG severity measured with Myasthenia Gravis Foundation of America (MGFA), mainly grades IIB (odds ratio 0.14 [95% CI 0.02-0.85], = .03) and IIIB (odds ratio 0.02 [95% CI 0.01-0.34], = .01).
Conclusions: Home NIV was needed in a substantial percentage of medically stable subjects with MG, mainly in those with generalized type and with oropharyngeal and/or respiratory muscle involvement (MGFA grades IIB and IIIB).
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10984589 | PMC |
| http://dx.doi.org/10.4187/respcare.11308 | DOI Listing |
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