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HFD-exacerbated Metabolic Side Effects of Olanzapine Are Suppressed by ER Stress Inhibitor.
Curr Med Sci
December 2023
School of Chemistry, Chemical Engineering and Life Sciences, Wuhan University of Technology, Wuhan, 430070, China.
Objective: Numerous schizophrenic patients are suffering from obesity primarily attributed to antipsychotic medication and poor dietary habits. This study investigated the progressive deterioration of olanzapine-induced metabolic disorders in the presence of a high-fat diet (HFD) and explored the involvement of endoplasmic reticulum (ER) stress.
Methods: Female Sprague-Dawley rats fed on a standard chow diet or HFD were treated with olanzapine (3 mg/kg/day) and the ER stress inhibitor 4-phenylbutyric acid (4-PBA, 1 and 0.
Olanzapine-induced progressive facial oedema mimicking Morbihan disease.
Clin Exp Dermatol
January 2024
Dermatology Department, University Hospital Limerick, Dooradoyle, Limerick, Ireland.
Activation of the PERK-CHOP signaling pathway during endoplasmic reticulum stress contributes to olanzapine-induced dyslipidemia.
Acta Pharmacol Sin
March 2024
School of Pharmaceutical Sciences, Medical Research Institute, Southwest University, Chongqing, 400715, China.
Olanzapine (OLZ) is a widely prescribed antipsychotic drug with a relatively ideal effect in the treatment of schizophrenia (SCZ). However, its severe metabolic side effects often deteriorate clinical therapeutic compliance and mental rehabilitation. The peripheral mechanism of OLZ-induced metabolic disorders remains abstruse for its muti-target activities.
View Article and Find Full Text PDFA Case of Olanzapine-Induced Cutaneous Eruption.
Am J Case Rep
October 2023
Department of Behavioral Medicine and Psychiatry, West Virginia University School of Medicine, Martinsburg, WV, USA.
BACKGROUND Different medication classes have been implicated in cutaneous eruptions that may lead to significant morbidity and mortality. In drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome, the patient may initially present with a cutaneous eruption and hematologic abnormalities which can lead to acute visceral organ involvement if the offending drug is not discontinued. There is also a potential for long-term sequelae such as autoimmune disorders.
View Article and Find Full Text PDFLate-Onset Dystonia With Low-Dose Olanzapine in an Older Person: A Case Report.
Sr Care Pharm
October 2021
3Director of Inpatient Geriatric Medicine Clinical Services, Brookdale Dept. of Geriatrics and Palliative Medicine, Icahn School of Medicine at Mount Sinai, New York, New York.
Drug-induced dystonias are rare but can occur with second-generation antipsychotics. They are usually dose-related and occur soon after dose initiation. This case describes the development of dystonia after two years of olanzapine 5 mg daily in an older person with Alzheimer's dementia.
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