AI Article Synopsis
- This study highlights the importance of pH adaptation for a human pathogen's colonization and disease-causing abilities.
- The research identifies a new regulatory pathway, Rfg1-Bcr1, that specifically manages responses to acidic pH and influences filamentous growth.
- Additionally, it shows how other signaling pathways and transcription factors work together to regulate these processes in the pathogen.
Article Abstract
is a human commensal and frequent pathogen that encounters a wide range of pH stresses. The ability of to adapt to changes in extracellular pH is crucial for its success in colonization and pathogenesis. The Rim101 pH sensing pathway is well known to govern neutral-alkaline pH responses in this pathogen. Here, we report a novel Rfg1-Bcr1 regulatory pathway that governs acidic pH responses and regulates filamentous growth in . In addition, the Rim101-Phr1 pathway, cAMP signaling pathway, transcription factors Efg1 and Flo8, and hyphal-specific G1 cyclin Hgc1 cooperate with this regulation. Our findings provide new insights into the regulatory mechanism of acidic pH response in .
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10715123 | PMC |
| http://dx.doi.org/10.1128/spectrum.01789-23 | DOI Listing |
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