High-risk HPV-associated ovarian squamous cell carcinoma: A case report and literature review.

Medicine (Baltimore)

Department of Obstetrics and Gynecology; Guangdong Provincial Key Laboratory of Major Obstetric Diseases; Guangdong Provincial Clinical Research Center for Obstetrics and Gynecology; Guangdong-Hong Kong-Macao Greater Bay Area Higher Education Joint Laboratory of Maternal-Fetal Medicine, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.

Published: November 2023

AI Article Synopsis

  • Ovarian squamous cell carcinoma (OSCC) is a rare type of cancer, and cases related to high-risk HPV, like HPV-16, are even less common.
  • A patient discovered an 8-cm ovarian cyst during a routine ultrasound, leading to surgery where they were diagnosed with HPV-16-related OSCC that affected nearby uterine tissue.
  • Despite having cleared HPV in the past, it's important for patients, especially those with a history of cervical issues, to stay vigilant for rare cancers like high-risk HPV-related OSCC, even when annual screenings seem negative.

Article Abstract

Rationale: Ovarian squamous cell carcinoma (OSCC) is an exceedingly rare subtype, and high-risk human papillomavirus (HPV)-related OSCC is even rarer.

Patient Concerns: An 8-cm diameter ovarian cyst was detected during a routine B-ultrasound examination, and the patient underwent laparoscopic surgery. Postoperative pathological examination revealed HPV-16-related OSCC involving adjacent uterine tissue. The patient received postoperative radiotherapy and chemotherapy.

Diagnoses: High-risk HPV-related OSCC.

Interventions: No.

Outcomes: The patient was finally diagnosed with high-risk HPV-related OSCC and underwent surgical treatment.

Lessons Subsections: In patients with high-grade cervical intraepithelial neoplasia who have undergone cervical conization and maintained annual HPV negativity, the possibility of high-risk HPV-related OSCC should be considered, despite its extreme rarity. Vigilance is essential in the presence of ovarian cysts even after HPV clearance.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10627682PMC
http://dx.doi.org/10.1097/MD.0000000000035907DOI Listing

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