AI Article Synopsis
- * The lncRNA X-inactive specific transcript (XIST) is particularly important as it is downregulated early in ischemic stroke but increases later, influencing the disease through its interactions with various miRNAs and transcription factors.
- * This review examines the role of XIST in ischemic stroke, aiming to provide insights into its mechanisms and explore potential new targets for treatment.
Article Abstract
Ischemic stroke, which occurs due to the occlusion of cerebral arteries, is a common type of stroke. Recent research has highlighted the important role of long non-coding RNAs (lncRNAs) in the development of cerebrovascular diseases, specifically ischemic stroke. Understanding the functional roles of lncRNAs in ischemic stroke is crucial, given their potential contribution to the disease pathology. One noteworthy lncRNA is X-inactive specific transcript (XIST), which exhibits downregulation during the early stages of ischemic stroke and subsequent upregulation in later stages. XIST exert its influence on the development of ischemic stroke through interactions with multiple miRNAs and transcription factors. These interactions play a significant role in the pathogenesis of the condition. In this review, we have provided a comprehensive summary of the functional roles of XIST in ischemic stroke. By investigating the involvement of XIST in the disease process, we aim to enhance our understanding of the mechanisms underlying ischemic stroke and potentially identify novel therapeutic targets.
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| http://dx.doi.org/10.1007/s12035-023-03740-x | DOI Listing |
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