5α,8α-peroxyergosteryl divaricatinate () is isolated for the first time from acetone extract of the thallus of cf. together with condidymic (), isodidymic () and barbatic () acids. Their UVB/UVA photoprotective and antioxidant activities were determined along with their cyto- and DNA-protecting actions against OH• damage. Compound showed high UVA, cyto- (%cell viability 82 at 15 µM 71 for OH•) and DNA (%DNA-integrity 74 at 100 µM 22 for OH•) protecting properties. Compounds and exhibited high UVB (SPF 40) and antioxidant activities (free radical scavenging potency EC = 0.6694 and 1.700 mol compound/mol DPPH•; ferric reducing power 0.392 and 0.546, at 500 ppm and inhibited lipid peroxidation); protecting cells (%cell viability 76 at 15 µM) and DNA (%DNA-integrity 57 at 100 µM). Compounds to fulfilled some physicochemical properties to act topically on the skin.
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