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Costunosides A-C: cytotoxic sesquiterpene lactones from the rhizomes of Falc. | LitMetric
Three new eudesmane type rare sesquiterpene lactone galactosides, costunosides A-C ( were isolated from the rhizomes of along with ten known compounds (). Costunosides A-C ( are the first example of naturally eudesmane glycosides containing a -galactopyranoside moiety. The structure and relative configurations of these compounds were established by comprehensive analysis of MS and, in particular 1D/2D NMR spectroscopic data. The isolated compounds were tested against a panel of human cancer cell lines, where compounds and have shown promising cytotoxic activity against PC-3, HCT-116 and A549 cell lines with IC values in the range of 3.4 µM to 9.3 µM, respectively. Costunosides A-C ( were also screened for inhibition assay of acetyl-cholinesterase (AChE), and butyrylcholinesterase (BChE) and found inactive at a concentration of 10 µM.
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Three new eudesmane type rare sesquiterpene lactone galactosides, costunosides A-C ( were isolated from the rhizomes of along with ten known compounds (). Costunosides A-C ( are the first example of naturally eudesmane glycosides containing a -galactopyranoside moiety. The structure and relative configurations of these compounds were established by comprehensive analysis of MS and, in particular 1D/2D NMR spectroscopic data.
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