AI Article Synopsis
- This text discusses a method for iodinating Weinreb amides, which are difficult to work with in chemical reactions, using an easily accessible catalyst.
- The process allows for selective iodination of both Weinreb amides and benzamides under mild conditions while being resistant to air and moisture.
- It highlights potential industrial uses and shows that the method can also be carried out using mechanochemical techniques, without affecting the reaction's effectiveness and selectivity.
Article Abstract
The acid mediated -iodination of Weinreb amides using a readily available catalyst is described. The selective -iodination of Weinreb amides, challenging substrates in directed C-H activations, and also of benzamides is achieved. The process works under mild conditions and tolerates air and moisture, having a great potential for industrial applications. The methodology can be applied under mechanochemical conditions maintaining the reaction outcome and selectivity.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11019638 | PMC |
| http://dx.doi.org/10.1021/acs.orglett.3c03190 | DOI Listing |
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