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Background: Gastric cancer (GC) has a poor prognosis, considerable cellular heterogeneity, and ranks fifth among malignant tumours. Understanding the tumour microenvironment (TME) and intra-tumor heterogeneity (ITH) may lead to the development of novel GC treatments.
Methods: The single-cell RNA sequencing (scRNA-seq) dataset was obtained from the Gene Expression Omnibus (GEO) database, where diverse immune cells were isolated and re-annotated based on cell markers established in the original study to ascertain their individual characteristics.
Targeted Covalent Nanodrugs Reinvigorate Antitumor Immunity and Kill Tumors via Improving Intratumoral Accumulation and Retention of Doxorubicin.
ACS Nano
January 2025
Molecular Science and Biomedicine Laboratory (MBL), State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Aptamer Engineering Center of Hunan Province, Hunan University, Changsha, Hunan 410082, China.
Specifically improving the intratumoral accumulation and retention and achieving the maximum therapeutic efficacy of small-molecule chemotherapeutics remains a considerable challenge. To address the issue, we here reported near-infrared (NIR) irradiation-activatable targeted covalent nanodrugs by installing diazirine-labeled transferrin receptor 1 (TfR1)-targeted aptamers on PEGylated phospholipid-coated upconversion nanoparticles followed by doxorubicin loading. Targeted covalent nanodrugs recognized and then were activated to covalently cross-link with TfR1 on cancer cells by 980 nm NIR irradiation.
View Article and Find Full Text PDFPrognostic factors for overall survival in elderly patients with glioblastoma: Analysis of the pooled NOA-08 and Nordic trials with the CCTG-EORTC (CE.6) trial.
Neurooncol Adv
December 2024
Odette Cancer Centre, Department of Medicine, University of Toronto, Toronto, Canada.
Background: The majority of patients diagnosed with glioblastoma are >60 years. Three randomized trials addressed the roles of radiotherapy (RT) and temozolomide (TMZ) for elderly patients. NORDIC and NOA-08 compared RT versus TMZ, while CE.
View Article and Find Full Text PDFChironomids (Diptera) from Central European stream networks: new findings and taxonomic issues.
Biodivers Data J
December 2024
University of Pécs, Faculty of Sciences, Department of Hydrobiology, Ifjúság útja 6, Pécs, Hungary University of Pécs, Faculty of Sciences, Department of Hydrobiology, Ifjúság útja 6 Pécs Hungary.
Background: Chironomidae, with over 7,300 described species, are amongst the most diverse and abundant insect families in freshwater ecosystems worldwide. Chironomids are known for their widespread distribution from various water types. The level of documentation of chironomid fauna varies considerably amongst European countries, with more comprehensive knowledge for Western Europe compared to other regions.
View Article and Find Full Text PDFThe reverse water gas shift reaction (RWGS) mechanism study on the γ-MoC(100) surface.
RSC Adv
January 2025
Institute of Molecular Science, Key Laboratory of Chemical Biology and Molecular Engineering of Ministry of Education, Shanxi University Taiyuan 030006 China
CO conversion and reuse technology are crucial for alleviating environmental stress and promoting carbon cycling. Reverse water gas shift (RWGS) reaction can transform inert CO into active CO. Molybdenum carbide (MoC) has shown good performance in the RWGS reaction, and different crystalline phases exhibit distinct catalytic behaviors.
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