Treatment of rheumatoid arthritis with curcumin analog 3,5-bis(arylidene)-4-piperidone.

Rheumatoid arthritis (RA) is an inflammatory disease. Curcumin can inhibit NF-κB and reduce the expression of inflammation-related genes. To evaluate the potential development of in the clinical treatment of inflammatory diseases such as RA. Using a skeleton fusion strategy to synthesize curcumin analogues for . This work evaluates anti-inflammatory activity by conducting anti-arthritis experiments (adjuvant-induced RA models) on rats. Western blot and ELISA were used to detect the expression of inflammatory-related proteins and cytokines. Molecular docking analysis confirmed the binding effect of with active sites. inhibits NF-κB has a protective effect on arthritis caused by RA.