Characterization of pharmacogenetic variation in African populations and comparison with other global populations.

is important in the metabolism of clopidogrel and several antidepressants. This study aimed to characterize the distribution of star alleles (haplotypes) across diverse African populations compared with global populations. star alleles and diplotypes were called from high coverage genomes using the StellarPGx pipeline. (51%), (17%) and (22%) were the most common star alleles across African populations in this study. It was observed that 3% of African participants had potentially novel haplotypes. This study supports the necessity for pharmacogenetic testing in African and global clinical settings, as well as the importance of comprehensive star allele characterization in the African context.