AI Article Synopsis
- Ulcerative colitis (UC) is a chronic inflammatory bowel disease, and there are concerns about potential triggers that can cause flare-ups.
- A 36-year-old man on isotretinoin for severe acne experienced a UC flare after four months, presenting symptoms like bloody diarrhea, leading to a colonoscopy that confirmed ulcerative pancolitis.
- The patient's isotretinoin was stopped, and he was successfully treated with adalimumab and azathioprine, emphasizing the need for more research on the effects of isotretinoin in individuals with UC.
Article Abstract
Ulcerative colitis (UC) is an inflammatory bowel disease characterized by chronic intestinal inflammation. We present a case of UC flare induced by isotretinoin, a medication commonly used for the treatment of severe acne. A 36-year-old male with a history of UC in remission presented with moderate-severe cystic acne and was started on isotretinoin. After four months of treatment, he developed symptoms of UC flare, including bloody diarrhea. A colonoscopy revealed ulcerative pancolitis, and isotretinoin was discontinued. The patient was subsequently treated with adalimumab and azathioprine, achieving good disease control. This case highlights the potential link between isotretinoin and UC exacerbation, suggesting the need for further research to understand the underlying mechanisms and assess the risk associated with isotretinoin use in patients with UC.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10621878 | PMC |
| http://dx.doi.org/10.7759/cureus.46429 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!