AI Article Synopsis
- The study aimed to identify clinical markers related to cognitive and motor functions that predict phenoconversion and phenotypes in patients with isolated rapid eye movement sleep behavior disorder (iRBD).
- A total of 45 iRBD patients and 25 healthy individuals underwent comprehensive evaluations, which revealed that 21 patients experienced phenoconversion over an average follow-up of nearly three years.
- Key findings indicated that certain cognitive tests—especially the Trail Making Test (TMT) and Alternate-tap Test (ATT)—were effective in predicting phenoconversion, with attention-executive and motor functions being strong indicators for motor phenotypes, while cognitive functions mainly indicated cognitive phenotypes.
Article Abstract
Objective: To determine the clinical markers based on cognitive and motor profiles in predicting phenoconverion and phenotype in isolated rapid eye movement sleep behavior disorder (iRBD).
Methods: 45 iRBD patients and 25 healthy controls were included in the follow-up study. All participates received comprehensive evaluations of cognitive, motor and autonomic function at baseline. Positive phenoconversion were identified according to standard diagnostic criteria during follow-up.
Results: 21 iRBD patients displayed phenoconversion in a mean follow-up of 2.9 ± 1.6 years, with 14 presenting motor phenotype and 7 cognitive phenotype. In iRBD, visuospatial, memory, attention-executive function, information processing speed, and motor function predicted phenoconversion, with the combination of Trail Making Test (TMT) and Alternate-tap Test (ATT) performing best (sensitivity = 95.0 %, specificity = 75.0 %); attention-executive function, information processing speed, and motor function predicted motor phenotype conversion, with the combination of TMT and ATT performing best (sensitivity = 100 %, specificity = 66.7 %); visuospatial, memory, and attention-executive function predicted cognitive phenotype conversion, with TMT performing best (sensitivity = 83.3 %, specificity = 91.7 %). Furthermore, individuals with lower z-scores of TMT, Symbol Digit Modalities Test, and ATT than the established cutoff values in iRBD exhibited a significantly higher risk for phenoconversion at follow-up (HR = 2.98, 9.53, 11.68; respectively).
Conclusions: In iRBD, the attention-executive and motor function served as optimum combined markers in predicting phenoconversion and motor phenotype, whereas the attention-executive function performed best in predicting cognitive phenotype. Poor attention-executive function, information processing speed and motor function in iRBD independently increased the risk of phenoconversion.
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| http://dx.doi.org/10.1016/j.sleep.2023.10.027 | DOI Listing |
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