AI Article Synopsis
- The text describes the rearrangement of a specific chemical compound to create new derivatives of a less-known system.
- The synthesis process for various 2-N-substituted derivatives is detailed.
- Some newly synthesized compounds exhibited significant pain-relieving effects in pharmacological tests.
Article Abstract
A rearrangement of 2H-2-acetonyl(phenacyl)-4,6-dimethyl- pyrido[3,2-d]isothiazoline-3-one-1,1-dioxides (I), (II) to derivatives of the unknown system of 2H-pyrido[3,2-e]-1,2-thiazine-1,1-dioxide (V), (XIII) is described; the synthesis of 2-N-substituted derivatives (VI - XII), (XIV - XVI) is also given. The structures of the new compounds were confirmed with elemental analyses and spectral data (I.R., N.M.R., MS). Some of the newly obtained compounds showed strong analgesic activity upon pharmacological screening.
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