Corn, rice, wheat, and sugar are major sources of food calories consumption thus the massive agricultural waste (AW) is generated through agricultural and agro-industrial processing of these raw materials. Biological conversion is one of the most sustainable AW management technologies. The abundant supply and special structural composition of cellulose, hemicellulose, and lignin could provide great potential for waste biological conversion. Conversion of hemicellulose to xylitol, cellulose to ethanol, and utilization of remnant whole cells biomass to synthesize phenylacetylcarbinol (PAC) are strategies that are both eco-friendly and economically feasible. This co-production strategy includes essential steps: saccharification, detoxification, cultivation, and biotransformation. In this review, the implemented technologies on each unit step are described, the effectiveness, economic feasibility, technical procedures, and environmental impact are summarized, compared, and evaluated from an industrial scale viewpoint.
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http://dx.doi.org/10.1016/j.biortech.2023.129926 | DOI Listing |
J Agric Food Chem
January 2025
School of Biotechnology and Key Laboratory of Industrial Biotechnology Ministry of Education, Jiangnan University, Wuxi 214122, China.
d-Tagatose, a rare sugar endowed with a low-calorie property, superior taste quality, and probiotic functionality, has garnered significant research attention. However, the prevailing biological production methods relying on β-galactosidase and l-arabinose isomerase face challenges including high cost and suboptimal conversion efficiency. Consequently, it is of great research significance to find efficient alternative routes for d-tagatose synthesis.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
University of Pittsburgh, Pittsburgh, PA, USA.
Background: The bi-directional autophagy and inflammation network becomes progressively dysregulated with age, with systemic inflammation as a biomarker of this dysregulation including in Alzheimer's Disease (AD). We hypothesize that interventions which target the shared feature of systemic inflammation in the biology of aging and AD, via regulation of the autophagy-inflammation network, will prevent the conversion to disease pathogenesis in AD as well as improve healthspan and longevity in aging populations. While previous studies report benefits of mTOR inhibition including rapamycin in transgenic mouse models of familial AD, the present studies aim to evaluate this pathway in a model of sporadic, late onset AD (LOAD) and test the contribution of AMP-activated protein kinase (AMPK) as a critical regulator of the mTOR pathway.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
Peking University Institute of Mental Health (Sixth Hospital), Beijing, China.
Background: This study aimed to explore the association between amyloid-β oligomerization tendency (OAβ) in plasma and cognitive performance in patients with Alzheimer's disease (AD) and further determine whether plasma OAβ could predict the outcomes of patients with mild cognitive impairment (MCI).
Method: The plasma from 727 subjects in a case registry was tested; these subjects included 286 AD patients, 260 MCI patients and 181 normal controls. The multimer detection system (MDS) was used to measure the plasma oligomeric form of Aβ levels.
Alzheimers Dement
December 2024
Knight Alzheimer Disease Research Center, St. Louis, MO, USA.
Background: The ability to detect cognitive impairment from Alzheimer Disease (AD) in its earliest possible symptomatic stage is a highly desirable characteristic for neuropsychological measures. Because early cognitive changes are often subtle, measures with high sensitivity are of great importance. Variability in attention, often assessed using reaction time (RT) tasks, have been shown to discriminate between cognitively normal older individuals with and without positive AD biomarkers and is correlated with biological markers of neurodegeneration.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
Washington University in St. Louis, St. Louis, MO, USA.
Background: Cognitive reserve (CR) has emerged as a critical factor in understanding clinical-cognitive heterogeneity in Alzheimer's disease (AD). However, there is limited evidence of the effect of CR during asymptomatic phases of the disease, age at symptom onset (AAO) and longitudinal decline. In this study, we elucidate the impact of CR on AAO and decline rate using Dominantly Inherited Alzheimer's Disease (DIAD) as a disease progression model.
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