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Sepsis-induced NET formation requires MYD88 but is independent of GSDMD and PAD4.
FASEB J
January 2025
Institute of Clinical Chemistry and Laboratory Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Neutrophils are peripheral blood-circulating leukocytes that play a pivotal role in host defense against bacterial pathogens which upon activation, they release web-like chromatin structures called neutrophil extracellular traps (NETs). Here, we analyzed and compared the importance of myeloid differentiation factor 88 (MYD88), peptidyl arginine deiminase 4 (PAD4), and gasdermin D (GSDMD) for NET formation in vivo following sepsis and neutrophilia challenge. Injection of lipopolysaccharide (LPS)/E.
View Article and Find Full Text PDFA Natural Disaster Exacerbates and Redistributes Disease Risk Among Free-Ranging Macaques by Altering Social Structure.
Ecol Lett
January 2025
Department of Cellular and Molecular Biology, Harvard University, Cambridge, Massachusetts, USA.
Article Synopsis
- Climate change is increasing extreme weather events, which can impact animal social structures and affect disease spread.
- By studying rhesus macaques before and after a hurricane, research shows that disease transmission rates can double for up to 5 years post-disaster.
- The hurricane changed how infection risk is spread within the population, highlighting that natural disasters not only threaten wildlife health but also pose risks of disease spilling over to humans.
The Russian dandelion () is a promising source of natural rubber (NR). The synthesis of NR takes place on the surface of organelles known as rubber particles, which are found in latex - the cytoplasm of specialized cells known as laticifers. As well as the enzymes directly responsible for NR synthesis, the rubber particles also contain small rubber particle proteins (SRPPs), the most abundant of which are SRPP3, 4 and 5.
View Article and Find Full Text PDFMalaria elimination challenges in countries approaching the last mile: a discussion among regional stakeholders.
Malar J
December 2024
Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.
Background: The national malaria control programmes in Cambodia, Nepal, and Bhutan aim to achieve malaria elimination by 2025-2030. While the vivax malaria burden remains challenging, the consistent decline in falciparum malaria in these countries over the last five years suggests that the goal is achievable. However, unexpected cases in previously falciparum malaria-free districts continue to occur.
View Article and Find Full Text PDFScholars in Health Equity: A Program of Structured Physician Faculty Development.
J Gen Intern Med
December 2024
Department of Medicine, Weill Cornell Medicine, New York, NY, USA.
Background: Structured faculty development programs focused on integrating health equity into medical education curricula remain limited.
Aim: To describe an interdisciplinary faculty development program grounded in adult learning theory and to assess its impact on participants' professional growth.
Setting And Participants: Twenty-one faculty members across six academic-affiliated health systems.
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