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gene polymorphisms are associated with cyclophosphamide effectiveness in lupus nephritis patients: A case-control study in Indonesia.
Narra J
December 2024
Department of Pharmacology-Clinical Pharmacy, School of Pharmacy, Institut Teknologi Bandung, Bandung, Indonesia.
Glutathione-S-transferase alpha-1 () is an enzyme with high conjugation activity against aldophosphamide, a metabolite of cyclophosphamide and promoter polymorphisms in may influence the cyclophosphamide effectiveness. The aim of this study was to evaluate the effectiveness and side effects of cyclophosphamide in lupus nephritis patients, using variants as predictors. A case-control study was conducted at Hasan Sadikin Hospital, Bandung, Indonesia, involving 100 lupus nephritis patients from February 2023 to January 2024.
View Article and Find Full Text PDFReplacement of fishmeal with Quinoa Husk (Chenopodium quinoa) for mitigating multiple stresses in Pangasianodon Hypophthalmus.
Sci Rep
January 2025
ICAR-National Institute of Abiotic Stress Management, Baramati, Pune, 413115, India.
The fishmeal is boon for aquaculture production in this recent pollution and climate change era. However, the demand of fishmeal is enhancing in many folds which needs to find alternative to fishmeal in cheap price. The present investigation addresses these issues with quinoa husk (QH).
View Article and Find Full Text PDFGenome-wide analyses of glutathione S-transferase gene family and expression profiling among three haplotypes Aphis gossypii.
Comp Biochem Physiol Part D Genomics Proteomics
January 2025
College of Plant Protection, Yangzhou University, Yangzhou 225009, Jiangsu, China. Electronic address:
Glutathione S-transferase (GST) plays a critical role in detoxifying various chemical compounds and is essential for host adaptation and pesticide resistance in insects. To understand the genetic structure of the GST family and the expression patterns among three haplotypes of Aphis gossypii, we conducted studies using genome annotation files and RNA-seq data. We identified 11 GSTs in A.
View Article and Find Full Text PDFMetabolomics approach to evaluate diclazuril-induced developmental toxicity in zebrafish embryo.
Aquat Toxicol
January 2025
Analytical Chemistry Laboratory, ASSIST Group, Main campus, CSIR-Indian Institute of Toxicology Research (CSIR-IITR), Vishvigyan Bhavan, 31, Mahatma Gandhi Marg, Lucknow 226001, Uttar Pradesh, India; Academy of Scientific and Innovative Research (AcSIR), CSIR-IITR Campus, Lucknow India. Electronic address:
Anticoccidials, commonly used in veterinary medicine to treat coccidiosis in food-producing animals, particularly in poultry farming, are associated with potential environmental risks due to their excretion in manure and subsequent land-spreading. Diclazuril, a widely used anticoccidial, has been detected in groundwater, raising concerns about its impact on non-target species. This study investigates the developmental toxicity of diclazuril in zebrafish embryos over a 96-hour exposure period, utilizing biomarkers such as oxidative stress indicators and metabolomic profiles.
View Article and Find Full Text PDFIntegrative biomonitoring in Litopenaeus vannamei: Metal analysis and biochemical markers.
Mar Pollut Bull
January 2025
ICAR-National Institute of Abiotic Stress Management, Baramati, Pune-413115, India.
Contaminants are a major cause of seafood export rejections in foreign markets and have significantly impacted consumer health. This investigation addresses the issues of metal contamination and biochemical markers in Litopenaeus vannamei from East Midnapore, West Bengal, India. The analyzed metals included vanadium (V), chromium (Cr), manganese (Mn), cobalt (Co), nickel (Ni), copper (Cu), zinc (Zn), molybdenum (Mo), silver (Ag), gallium (Ga), germanium (Ge), arsenic (As), selenium (Se), strontium (Sr), tin (Sn), cadmium (Cd), mercury (Hg), and lead (Pb), using Inductively Coupled Plasma Mass Spectrometry (ICP-MS).
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