Disordered protein regions partner up the cBAF remodeler for a chromatin dance.

Mol Cell

Biomedical Center Munich, Faculty of Medicine, LMU Munich, Planegg, Martinsried, Germany; Eisbach Bio GmbH, Planegg, Martinsried, Germany; International Max Planck Research School (IMPRS) for Molecules of Life, Planegg, Martinsried, Germany. Electronic address:

Published: November 2023

Intrinsically disordered protein regions form condensates and mediate interactions with factors that regulate gene activity. Patil et al. decode how such regions within the chromatin remodeler cBAF choreograph self-condensation and non-self interactions with transcriptional regulators, potentially impacting disease.

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http://dx.doi.org/10.1016/j.molcel.2023.10.002DOI Listing

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