AI Article Synopsis
- MTHFD2 is a key enzyme involved in one-carbon metabolism that is overexpressed in various cancers, aiding in tumor growth and metastasis while linked to worse patient survival.
- Recent research has focused on small-molecule inhibitors targeting MTHFD2 and MTHFD1, demonstrating potential in cancer treatment through diverse mechanisms.
- The review examines our current knowledge of MTHFD2's role in cancer and the progress of therapeutic inhibitors for cancers with elevated MTHFD2 levels.
Article Abstract
The one-carbon folate enzyme methylenetetrahydrofolate dehydrogenase/cyclohydrolase 2 (MTHFD2) is a promising therapeutic target in cancer. MTHFD2 is upregulated across numerous cancer types, promotes growth and metastasis of cancer, and correlates with poorer survival. Recent studies have developed small-molecule inhibitors to the isozymes MTHFD2 and MTHFD1 that show promise as anticancer agents through different mechanisms. This review discusses the current understanding of the function of MTHFD2 in cancer and the status of inhibitors for treating MTHFD2-overexpressing cancers.
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| http://dx.doi.org/10.1158/0008-5472.CAN-23-1290 | DOI Listing |
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