Introduction: Respiratory viral infections (RVI) in lung transplant recipients (LTR) have variably been associated with rejection and chronic lung allograft dysfunction. Our center has used systemic corticosteroids to treat outpatient RVI in some cases, but evidence is limited. We reviewed all adult LTR diagnosed with outpatient RVI January 2017 to December 2019. The primary outcome was recovery of lung function (forced expiratory volume in 1 s [FEV1]) at next stable visit between 1 and 12 months postinfection, expressed as a ratio over stable preinfection FEV1 (FEV1 recovery ratio).
Methods: We identified 100 adult LTR with outpatient RVI diagnoses eligible for study, 36% of whom received corticosteroids. We modelled the adjusted association between corticosteroid use and FEV1 recovery ratio using linear regression.
Results: Steroid-treated patients had a lower FEV1 presentation ratio (0.92 vs. 1.04, p = .0070) and were more likely to have chronic lung allograft dysfunction at time of infection (25% vs. 5%, p = .0077). Mean FEV1 recovery ratio was 1.02 (SD 0.19) with no association with corticosteroid therapy via multivariable linear regression (p = .5888).
Conclusions: Steroid treatment was not associated with FEV1 recovery. This suggests corticosteroids may not have a role in the management of RVI in this population.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1111/tid.14181 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Long-Term Pulmonary Sequelae and Immunological Markers in Patients Recovering from Severe and Critical COVID-19 Pneumonia: A Comprehensive Follow-Up Study.
Medicina (Kaunas)
November 2024
Clinic of Infectious Diseases and Dermatovenerology, Faculty of Medicine, Institute of Clinical Medicine, Vilnius University, 01513 Vilnius, Lithuania.
: Severe and critical COVID-19 pneumonia can lead to long-term complications, especially affecting pulmonary function and immune health. However, the extent and progression of these complications over time are not well understood. This study aimed to assess lung function, radiological changes, and some immune parameters in survivors of severe and critical COVID-19 up to 12 months after hospital discharge.
View Article and Find Full Text PDFEarly ambulation and chest tube removal are associated with postoperative day one discharge in majority of robotic pulmonary lobectomy patients at an ERAS center.
World J Surg
January 2025
Department of Thoracic Surgery, Virginia Mason Medical Center, Seattle, WA, USA.
Background: Application of enhanced recovery after surgery (ERAS) pathways in robotic lobectomy have been associated with decreased length of stay (LOS). We evaluated differences in patient characteristics and achievements of ERAS benchmarks by discharge groups at a tertiary referral center.
Materials And Methods: We performed a retrospective analysis of a prospectively maintained ERAS database of patients undergoing robotic lobectomy for pulmonary malignancy.
Hybrid Virtual Coaching and Telemonitoring in COPD Management: The CAir Randomised Controlled Study.
Int J Chron Obstruct Pulmon Dis
December 2024
Faculty of Medicine, University of Zurich, Zurich, Switzerland.
Objective: To investigate the effectiveness of 12-weeks hybrid virtual coaching on health-related quality-of-life (HrQoL) in patients with stable COPD.
Methods: We equipped all patients with a CAir Desk for telemonitoring, the intervention group additionally received hybrid virtual coaching through the built-in smartphone. The multimodal intervention based on the Living well with COPD programme, containing educational content, physical activity coaching, and home-based exercises.
Evaluation of Vocal and Pulmonary Health Through Acoustic Analysis of Voice and Respiratory Measurements in People With Long COVID-19 Symptoms.
J Voice
December 2024
Department of Music, Faculty of Human Ecology, Universiti Putra Malaysia, 43400 Serdang, Selangor, Malaysia. Electronic address:
Background/objectives: The coronavirus disease (COVID-19) pandemic has significantly impacted global health, with Malaysia reporting over 5 million cases as of May 2024. While symptoms like fatigue and breathlessness are commonly reported among COVID-19 patients, limited research exists on the vocal and pulmonary conditions of individuals with long COVID symptoms. This study aims to assess vocal impairments and pulmonary function differences between long COVID patients and healthy controls, addressing gaps in understanding how long COVID affects vocal and respiratory health.
View Article and Find Full Text PDFLung Function Recovery from Pulmonary Exacerbations Treated with Oral Antibiotics in Primary Ciliary Dyskinesia.
Ann Am Thorac Soc
December 2024
The Hospital for Sick Children, Division of Respiratory Medicine, Translational Medicine, Research Institute, Toronto, Ontario, Canada.
Rationale: Patients with Primary Ciliary Dyskinesia (PCD) experience acute pulmonary exacerbations (PEx). In Cystic Fibrosis (CF), PEx treated with oral antibiotics (oPEx) were found to be related to short and long-term lung function deficits, however the impact oPEx on lung function in patients with PCD has not yet been assessed.
Objective: To assess the impact of oPEx on lung function recovery in PCD and determine the factors associated with poorer response.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!