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IP-10 and MIG are sensitive markers of early virological response to HIV-1 integrase inhibitors. | LitMetric

AI Article Synopsis

  • - The study examined the levels of IP-10 and MIG, inflammatory biomarkers during HIV-1 infection, and how they change after starting antiretroviral treatment (ART) in a group of 73 individuals from 2015 to 2021.
  • - Significant reductions in IP-10 and MIG were observed by day 20 after starting ART, continuing for 48 months, coinciding with decreases in HIV-1 RNA and increases in CD4+ counts.
  • - The research indicated notable early declines in MIG levels specifically in those receiving integrase inhibitor (INSTI)-based treatments, highlighting the relationship between HIV-1 viremia and these chemokines.

Article Abstract

Background: Interferon-inducible protein-10 (IP-10) and monokine induced by interferon-gamma (MIG) are chemokines recognized as inflammatory biomarkers during HIV-1 infection. We assessed their early and long-term dynamics after initiation of antiretroviral treatment (ART).

Methods: Persons with HIV-1 (PWH) aged>18 years starting their first ART in 2015-2021 in a prospective cohort (n=73) were included. IP-10 and MIG plasma levels were quantified using a multiplexed bead-based assay.

Results: IP-10 and MIG plasma levels showed a significant and consistent reduction following ART (80% integrase inhibitor [INSTI]-based) initiation, starting at day 20 and maintained throughout the study period (48 months), paralleling the HIV-1 RNA decay and CD4+ count recovery (p<0·001). At baseline, PWH≥ 50 years, CDC stage C and CD4+ count<350cells/mm had higher levels of IP-10 (p=0·022, p=0·001 and p=0·002, respectively) and MIG (p<0·001, p=0·024 and p=0·069, respectively). All of them matched their counterparts several months following ART initiation. MIG levels showed a greater decrease at day 10 in those treated with INSTI (p=0·038). Low-level HIV-1 viremia did not impact MIG or IP-10 levels.

Conclusion: Plasma IP-10 and MIG showed an early significant decline following ART initiation, with greater early declines in MIG levels in INSTI-based regimens. These findings suggest a strong impact of HIV-1 viremia on IP-10 and MIG levels.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10619723PMC
http://dx.doi.org/10.3389/fimmu.2023.1257725DOI Listing

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