In this paper, a double association-based evolutionary algorithm (denoted as DAEA) is proposed to solve many-objective optimization problems. In the proposed DAEA, a double association strategy is designed to associate solutions with each subspace. Different from the existing association methods, the double association strategy takes the empty subspace into account and associates it with a promising solution, which can facilitate the exploration of unknown areas. Besides, a new quality evaluation scheme is developed to evaluate the quality of each solution in subspace, where the convergence and diversity of each solution is first measured, and in order to evaluate the diversity of solutions more finely, the global diversity and local diversity is designed to measure the diversity of each solution. Then, a dynamic penalty coefficient is designed to balance the convergence and diversity by penalizing the global diversity distribution of solutions. The performance of DAEA is validated by comparing with five state-of-the-art many-objective evolutionary algorithms on a number of well-known benchmark problems with up to 20 objectives. Experimental results show that our DAEA has high competitiveness in solving many-objective optimizatiopn problems compared with the other compared algorithms.
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http://dx.doi.org/10.3934/mbe.2023771 | DOI Listing |
BMC Med Inform Decis Mak
June 2024
School of Computer Science and Technology, Hunan Institute of Technology, Hengyang, 421010, China.
Background: Compared with the time-consuming and labor-intensive for biological validation in vitro or in vivo, the computational models can provide high-quality and purposeful candidates in an instant. Existing computational models face limitations in effectively utilizing sparse local structural information for accurate predictions in circRNA-disease associations. This study addresses this challenge with a proposed method, CDA-DGRL (Prediction of CircRNA-Disease Association based on Double-line Graph Representation Learning), which employs a deep learning framework leveraging graph networks and a dual-line representation model integrating graph node features.
View Article and Find Full Text PDFMucosal Immunol
June 2024
Department of Physiology and Pharmacology, Snyder Institute for Chronic Diseases, Cumming School of Medicine, University of Calgary, Calgary, Canada. Electronic address:
The microbiome has emerged as a crucial modulator of host-immune interactions and clearly impacts tumor development and therapy efficacy. The microbiome is a double-edged sword in cancer development and therapy as both pro-tumorigenic and anti-tumorigenic bacterial taxa have been identified. The staggering number of association-based studies in various tumor types has led to an enormous amount of data that makes it difficult to identify bacteria that promote tumor development or modulate therapy efficacy from bystander bacteria.
View Article and Find Full Text PDFMath Biosci Eng
September 2023
The Shaanxi Key Laboratory of Clothing Intelligence, School of Computer Science, Xi'an Polytechinic University, Xi'an 710048, China.
In this paper, a double association-based evolutionary algorithm (denoted as DAEA) is proposed to solve many-objective optimization problems. In the proposed DAEA, a double association strategy is designed to associate solutions with each subspace. Different from the existing association methods, the double association strategy takes the empty subspace into account and associates it with a promising solution, which can facilitate the exploration of unknown areas.
View Article and Find Full Text PDFInt J Chron Obstruct Pulmon Dis
June 2021
Department of Medicine, Pulmonary and Critical Care Medicine, Philipps University of Marburg (UMR), Marburg, Germany, Member of the German Center for Lung Research (DZL).
Background: Patients with chronic obstructive pulmonary disease (COPD) are at risk of developing cardiac arrhythmias and elevated heart rate. A theoretical mechanistic association based on the interaction of long-acting β-agonists (LABAs) with adrenoreceptors in the heart and vasculature is assumed as a potential class-related risk. Therefore, we performed a pooled analysis of Holter electrocardiogram (ECG) data from four 48-week, randomized, double-blind, placebo-controlled, parallel-group, Phase III clinical trials evaluating olodaterol (5 μg or 10 μg) or formoterol (12 µg) versus placebo.
View Article and Find Full Text PDFAnn Work Expo Health
August 2019
School of Population and Global Health, University of Western Australia, Perth, Western Australia, Australia.
Objectives: An asbestos job-exposure matrix (AsbJEM) has been developed to systematically and cost-effectively evaluate occupational exposures in population-based studies. The primary aim of this study was to examine the accuracy of the AsbJEM in determining exposure-response relationships between asbestos exposure estimates and malignant mesothelioma (MM) incidence (indirect validation). The secondary aim was to investigate whether the assumptions used in the development of the original AsbJEM provided accurate asbestos exposure estimates.
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