AI Article Synopsis
- Fibrils of the protein α-synuclein are linked to several neurodegenerative diseases, including Parkinson's Disease and Lewy Body Dementia.
- Researchers have utilized solid-state NMR methods to analyze various forms of α-synuclein fibrils and previously published resonance assignments.
- This study introduces a new set of carbon and nitrogen assignments specific to fibrils derived from the postmortem brain tissue of a Lewy Body Dementia patient.
Article Abstract
Fibrils of the protein α-synuclein (Asyn) are implicated in the pathogenesis of Parkinson Disease, Lewy Body Dementia, and Multiple System Atrophy. Numerous forms of Asyn fibrils have been studied by solid-state NMR and resonance assignments have been reported. Here, we report a new set of C, N assignments that are unique to fibrils obtained by amplification from postmortem brain tissue of a patient diagnosed with Lewy Body Dementia.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10863844 | PMC |
| http://dx.doi.org/10.1007/s12104-023-10156-0 | DOI Listing |
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