AI Article Synopsis

  • - The study examines how the diversity of motoneurons (MNs) and V2a interneurons (INs) in adult zebrafish contributes to the modular organization of motor circuits, which affects locomotor speed.
  • - It reveals that MNs and V2a INs can be categorized into slow, intermediate, or fast subtypes based on their molecular profiles, reflecting their specific roles in motor function.
  • - By identifying shared molecular characteristics among the different speed modules, the research sheds light on the fundamental molecular mechanisms behind neuronal diversity and the flexibility of motor actions.

Article Abstract

The flexibility of motor actions is ingrained in the diversity of neurons and how they are organized into functional circuit modules, yet our knowledge of the molecular underpinning of motor circuit modularity remains limited. Here we use adult zebrafish to link the molecular diversity of motoneurons (MNs) and the rhythm-generating V2a interneurons (INs) with the modular circuit organization that is responsible for changes in locomotor speed. We show that the molecular diversity of MNs and V2a INs reflects their functional segregation into slow, intermediate or fast subtypes. Furthermore, we reveal shared molecular signatures between V2a INs and MNs of the three speed circuit modules. Overall, by characterizing how the molecular diversity of MNs and V2a INs relates to their function, connectivity and behavior, our study provides important insights not only into the molecular mechanisms for neuronal and circuit diversity for locomotor flexibility but also for charting circuits for motor actions in general.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10774144PMC
http://dx.doi.org/10.1038/s41593-023-01479-1DOI Listing

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