Exclusion of Ranitidine From Premedication Regimens During Paclitaxel Treatment.

JAMA Oncol

Department of Clinical Pharmacology and Pharmacy, Amsterdam University Medical Center, Amsterdam, the Netherlands.

Published: January 2024

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10623296PMC
http://dx.doi.org/10.1001/jamaoncol.2023.4821DOI Listing

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Introduction: To minimize the risk of hypersensitivity reactions (HSRs) caused by paclitaxel infusion, premedication with corticosteroid, H1-antagonist and H2 antagonist (ranitidine) was standard of care. Discontinuation of ranitidine in 2020 led to adjustments in premedication regimens and a new regimen without ranitidine was implemented in our center. This study aimed to compare the incidence of HSRs during paclitaxel treatment of a standard premedication regimen including ranitidine with a new premedication regimen without ranitidine and with a titrated infusion rate during the first two administrations.

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