Isoxazole derivatives were synthesized via a one-pot method utilizing 2-methylquinoline derivatives as template substrates, sodium nitrite as a nitrogen-oxygen source, and solely using aluminum trichloride as the additive. This approach circumvents the need for costly or highly toxic transition metals and presents a novel pathway for the synthesis of isoxazole derivatives.
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| http://dx.doi.org/10.3762/bjoc.19.113 | DOI Listing |
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- The main goals were to create these new compounds, evaluate how they interact with COX-1/2 enzymes using computational methods, and test their anti-inflammatory effects in lab animals.
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