The manuscript describes the highly regioselective 6- iodo/bromo cyclization of functionalized -propagyl-amino-pyrimidinones under ambient conditions. The cyclization afforded functionalized pteridines in excellent yields. The optimized procedures are mild, operationally simple and working successfully with different substrates. The synthesis of functionalized pteridines is of great significance because of their potential pharmacological profile.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10616752 | PMC |
| http://dx.doi.org/10.1039/d3ra05651a | DOI Listing |
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