AI Article Synopsis
- - Thyroid cancer (TC) is the most common cancer of the endocrine system, with rising cases and related health issues globally, despite advancements in diagnostics and treatments.
- - The N6-methyladenosine (m6A) modification affects RNA metabolism and gene regulation, with its balance being disrupted by various regulators, which has implications for TC development and drug resistance.
- - This review looks at how m6A methylation impacts TC progression and explores the potential of m6A regulators as both prognostic indicators and targets for new therapies in treating the disease.
Article Abstract
Thyroid cancer (TC) is the most predominant malignancy of the endocrine system, with steadily growing occurrence and morbidity worldwide. Although diagnostic and therapeutic methods have been rapidly developed in recent years, the underlying molecular mechanisms in the pathogenesis of TC remain enigmatic. The N6-methyladenosine(m6A) RNA modification is designed to impact RNA metabolism and further gene regulation. This process is intricately regulated by a variety of regulators, such as methylases and demethylases. Aberrant m6A regulators expression is related to the occurrence and development of TC and play an important role in drug resistance. This review comprehensively analyzes the effect of m6A methylation on TC progression and the potential clinical value of m6A regulators as prognostic markers and therapeutic targets in this disease.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10621220 | PMC |
| http://dx.doi.org/10.1186/s40001-023-01382-2 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!