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Assessing gut barrier integrity and reproductive performance following pre-mating oral administration of solid-lipid-nanoparticles designed for drug delivery.
Front Toxicol
January 2025
Department of Biomedicine and Prevention, University of Rome Tor Vergata, Rome, Italy.
Solid lipid nanoparticles (SLNs) have gained interest as drug delivery carriers due to their efficient cellular internalization and increased therapeutic effect of the loaded drug, with minimal side effects. Although recently several studies have shown the possibility to administer SLNs during pregnancy to vehicle mRNA to the placenta, data about the effect of premating exposure to SLNs on pregnancy outcome are scant. Considering that assumption of drug-delivering nanocarriers in reproductive age may potentially affect women's reproductive health, the aim of the present study was to evaluate whether repeated oral administration of SLNs to female mice prior to mating would influence key pregnancy outcomes.
View Article and Find Full Text PDFBirth and pregnancy numbers decreased during the COVID-19 pandemic in Japan: A time series analysis with the ARIMA model.
J Obstet Gynaecol Res
January 2025
Department of Public Health, Dokkyo Medical University, School of Medicine, Tochigi, Japan.
Aim: The long-term effects of the COVID-19 pandemic on birth and pregnancy trends in Japan remain unclear. Although major sporting events are usually followed by an increase in births 9 months later, Japan's fifth wave of COVID-19 occurred during the Olympics held in Japan during the summer of 2021. In this study, we analyzed how the number of births and pregnancies changed during the COVID-19 pandemic and large-scale events in Japan.
View Article and Find Full Text PDFChallenges in Adolescent and Adult Males With Classic Congenital Adrenal Hyperplasia Due to 21-Hydroxylase Deficiency.
J Clin Endocrinol Metab
January 2025
Department of Molecular Medicine and Surgery, Karolinska Institutet, 171 76 Stockholm, Sweden.
Classic congenital adrenal hyperplasia (CAH) due to 21-hydroxylase deficiency results in severe cortisol and aldosterone deficiency, leading to persistent adrenal stimulation and excess production of ACTH and adrenal androgens. This review examines the clinical considerations and challenges of balancing under- and overtreatment with glucocorticoids in adolescent and adult male individuals with CAH. Adolescents face many unique challenges that can hinder adherence, hormonal control, and transition to independence.
View Article and Find Full Text PDFFertility desires in young men aged 18-24 living with HIV: a study across five Chinese provinces.
AIDS Care
February 2025
National Center for AIDS/STD Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, People's Republic of China.
Limited data exists concerning the fertility desires of young people living with HIV/AIDS (PLWHA) in China, making it difficult to develop appropriate reproductive health service policies and interventions for them. Extensive fieldwork was carried out from April to May 2021 in 10 selected survey sites across five provinces, targeting all young men aged between 18 and 24 years living with HIV. The association between independent variables and fertility desires was determined using Chi-square tests and Multivariate binary logistic regression models.
View Article and Find Full Text PDFUtilisation of Cryopreserved Gametes in Cancer Patients who Underwent Fertility Preservation.
J Hum Reprod Sci
December 2024
Department of Reproductive Medicine, Gunasheela Surgical and Maternity Hospital, Bengaluru, Karnataka, India.
Background: Cancer treatments such as chemotherapy and radiotherapy often compromise fertility by damaging gonadal function, creating a critical need for fertility preservation options. Despite advancements in fertility preservation techniques, there is a significant lack of research focused on their application in Asian cancer patients and their utilisation remains underexplored in this population.
Aim: This study aims to evaluate the utilisation rates and outcomes of cryopreserved gametes in cancer patients who underwent fertility preservation before their cancer treatment.
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