Planned Oocyte Cryopreservation: A Review of Current Evidence on Outcomes, Safety and Risks.

Obstet Gynecol Clin North Am

University of Southern California/Los Angeles General Medical Center, 2051 Marengo Street, Los Angeles, CA 90033, USA; HRC Fertility, 55 S Lake Avenue, Suite 900, Pasadena, CA 91101, USA.

Published: December 2023

Although oocyte cryopreservation was initially used as a fertility preservation strategy for medical indications, it is now is increasingly used to circumvent age-related infertility. Outcomes following planned oocyte vitrification, also known as elective egg freezing, are limited. Current studies show higher success rates for individuals undergoing fertility preservation treatment under age 35. Additionally, while freezing 20 oocytes is optimal to achieve pregnancy, freezing at least 8-10 oocytes is recommended. While fertility is not guaranteed, current evidence demonstrates that planned oocyte vitrification is an overall safe, low risk method of fertility preservation to reduce the risk for age-related infertility.

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ogc.2023.08.005DOI Listing

Publication Analysis

Top Keywords

planned oocyte
12
fertility preservation
12
oocyte cryopreservation
8
current evidence
8
age-related infertility
8
oocyte vitrification
8
cryopreservation review
4
review current
4
evidence outcomes
4
outcomes safety
4

Similar Publications

Background: Gonadotropin-releasing hormone agonists (GnRHa) are commonly used in assisted reproduction technology (ART) cycles to prevent a luteinising hormone (LH) surge during controlled ovarian hyperstimulation (COH) prior to planned oocyte retrieval, thus optimising the chances of live birth. We compared the benefits and risks of the different GnRHa protocols used.

Objectives: To evaluate the effectiveness and safety of different GnRHa protocols used as adjuncts to COH in women undergoing ART.

View Article and Find Full Text PDF

Development of a novel calculator to predict gonadotropin dose and oocyte yield in oocyte cryopreservation cycles.

J Assist Reprod Genet

January 2025

Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility, Northwestern University, Chicago, IL, USA.

Purpose: To develop a predictive model for estimating the total dose of gonadotropins and the number mature oocytes in planned oocyte cryopreservation cycles.

Methods: In this retrospective study, oocyte cryopreservation cycles recorded in the Society for Assisted Reproductive Technology Clinic Outcome Reporting System Database from 2013 to 2018 were analyzed. Bivariate copula additive models for location, scale, and shape were performed to create a predictive model for estimating total dose of gonadotropins and number of mature oocytes.

View Article and Find Full Text PDF

Pig production through crossbreeding methods is a pillar of the swine industry; however, research on the fertilization ability of male pigs in crossbreeds is lacking. Therefore, this study investigated the effects of Duroc sperm (DS) and Landrace sperm (LS) on fertility in Yorkshire × Landrace × Duroc (YLD) oocytes. Sperm were collected from the Duroc and Landrace species, and sperm characteristics, viability, and acrosome reactions were analyzed using flow cytometry.

View Article and Find Full Text PDF

Balancing choice and socioeconomic realities: analyzing behavioral and economic factors in social oocyte cryopreservation decisions.

Front Endocrinol (Lausanne)

January 2025

Department of Economics and Business Administration, Ariel University, Ariel, Israel.

Purpose: This research investigates the influence of personal income, the likelihood of pregnancy from cryopreserved oocytes, and the risk of infertility, on the decision-making process of women. The study employs the economic stated preference framework alongside the Theory of Planned Behavior in order to comprehend the process of decision-making.

Design/methodology/approach: The data had been collected from women between the ages of 18 and 65 via questionnaire employing conjoint analysis (CA).

View Article and Find Full Text PDF

Bona fide diminished ovarian reserve or profound ovarian suppression by long-term oral contraceptive use?

BMJ Case Rep

January 2025

Obstetrics and Gynecology; Divison of Reproductive Endocrinology and Infertility, University of Toronto, Toronto, Ontario, Canada

Combined oral contraceptives (COCs) are widely used by reproductive-aged women. Current data suggest that long-term use of COCs can suppress ovarian reserve markers, including anti-mullerian hormone and antral follicle count, which may negatively impact ovarian response and oocyte yield in patients undergoing planned oocyte cryopreservation to preserve future reproductive potential. Discontinuation of COCs can improve ovarian stimulation outcomes, though the ideal duration of cessation is unknown.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!