AI Article Synopsis
- The study investigates how the size of heart tissue damage (myocardial infarct) is connected to the blood flow provided by collateral vessels in anesthetized dogs during a controlled occlusion and reperfusion of the coronary artery.
- Findings indicate a strong relationship between collateral blood flow and myocardial damage, highlighting that differences in blood flow among individual dogs significantly influence the extent of tissue injury after a heart attack.
- It was also found that measuring blood flow before irreversible tissue damage occurs can help predict the eventual size of the infarct, potentially aiding in treatment decisions.
Article Abstract
The relationship between myocardial infarct size (measured by a histochemical stain) and coronary collateral blood flow (measured via retrograde flow and by use of radioactive microspheres) was studied in anesthetized dogs with high, moderate and low retrograde flows undergoing a 2-hour occlusion and 30-min reperfusion of the left anterior descending coronary artery. The results demonstrate that experimental myocardial infarct size is closely related to native coronary collateral blood flow, and the large variability in collateral perfusion amongst dogs is a source of variability in the mass of myocardium undergoing irreversible damage following acute coronary occlusion. Results also demonstrate that the variability in experimental infarct size can be reduced and ultimate infarct size predicted prior to irreversible tissue injury by initial measurement of retrograde coronary blood flow.
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| http://dx.doi.org/10.1159/000174027 | DOI Listing |
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