Purpose Of Review: Single-cell RNA sequencing studies have revealed transcriptional heterogeneity within the megakaryocytic lineage and the identified unique subsets. In this review, we discuss the functional and phenotypic plasticity of these subpopulations as well as the impacts on health and disease.
Recent Findings: Megakaryocytes (MKs) can be transcriptionally categorized into platelet generating, niche supporting, immune, and cycling cells, which are distinguished by their unique gene expression patterns and cellular markers. Additionally, a significant population of these cells has been established to reside in the nonhematopoietic tissues and they display enhanced immune-related characteristics. Combined with the location in which the megakaryocytes exist, these cells can play unique roles dictated by their current environment and biological needs, including responding to changes in pathogen exposure.
Summary: Advances in megakaryocyte research has elucidated the existence of multiple subpopulations of MKs that serve different functions. These subpopulations implicate a greater potential for MKs to be regulators of health and suggest new avenues for treatments and therapies in related diseases.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10842450 | PMC |
| http://dx.doi.org/10.1097/MOH.0000000000000793 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Highly efficient generation of mature megakaryocytes and functional platelets from human embryonic stem cells.
Stem Cell Res Ther
November 2024
Laboratory of Stem Cells and Translational Medicine, Institute for Clinical Medicine, the Second Affiliation Hospital, School of Medicine, South China University of Technology, No.1 Panfu Road, Guangzhou, 510180, People's Republic of China.
Article Synopsis
- Platelet transfusion therapy has advanced significantly, and the generation of functional platelets from human embryonic stem cells (hESCs) presents new possibilities, but challenges remain in efficiently producing these platelets.* -
- Researchers developed a method that uses hypoxic conditions and a specific combination of cytokines to effectively differentiate hESCs into mature megakaryocytes (MKs) and functional platelets, demonstrating strong maturation and functionality through various analyses.* -
- The study found that under the new 3D differentiation conditions, a high percentage of MKs and platelets showed the desired markers and functionality, with the generated hESC-derived platelets successfully restoring normal clotting in mouse models of thrombocytopenia.*
Immunological face of megakaryocytes.
Front Med
December 2024
China National Center for Bioinformation, Beijing, 100101, China.
Megakaryocytes (MKs), which are traditionally known for their role in platelet production, are now emerging as unique immune cells with diverse capabilities. They express immune receptors, participate in pathogen recognition and response, phagocytose pathogens, contribute to antigen presentation, and interact with various immune cell types. When encountering inflammatory challenges, MKs exhibit intricate immune functions that can either promote or inhibit inflammation.
View Article and Find Full Text PDFClinical characteristics, treatment, and outcomes of nivolumab induced immune thrombocytopenia.
Invest New Drugs
October 2024
College of pharmacy, Changsha Medical University, No. 1501 Leifeng Avenue, Xiangjiang New District, Changsha, Hunan, 410219, China.
Immune thrombocytopenia (ITP) represents an uncommon hematological side effect associated with nivolumab, and its distinct clinical attributes remain poorly defined. This research aimed to explore the clinical manifestations and outcomes of ITP induced by nivolumab. Reports on nivolumab induced ITP up to April 30, 2024, were collected for retrospective analysis.
View Article and Find Full Text PDFThe many faces of the megakaryocytes and their biological implications.
Curr Opin Hematol
January 2024
Vascular Biology Program, Boston Children's Hospital.
Purpose Of Review: Single-cell RNA sequencing studies have revealed transcriptional heterogeneity within the megakaryocytic lineage and the identified unique subsets. In this review, we discuss the functional and phenotypic plasticity of these subpopulations as well as the impacts on health and disease.
Recent Findings: Megakaryocytes (MKs) can be transcriptionally categorized into platelet generating, niche supporting, immune, and cycling cells, which are distinguished by their unique gene expression patterns and cellular markers.
Neoplastic bone marrow invasion:rapid exclusion of hematological disease by flow cytometric routine panels.
Blood Cells Mol Dis
March 2023
Hematology, Department of Translational and Precision Medicine, Sapienza University, 00161 Rome, Italy.
Article Synopsis
- * In some instances, cells may be of non-hemopoietic origin and show specific markers, making it challenging to determine their origin through traditional methods.
- * The study highlights six patients where multiparametric flow cytometry effectively ruled out blood disorders, allowing for timely and appropriate diagnosis.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!