AI Article Synopsis
- An IncFII plasmid (pIncFII-NDM5) linked to carbapenem-resistant serovar Typhimurium was identified, containing multiple antibiotic resistance genes that allow the bacteria to resist various antibiotics.
- Phylogenetic analysis revealed that certain strains were closely related to other local serovar Typhimurium, indicating the potential for increased antibiotic resistance when these strains acquire the plasmid.
- A novel genetic structure related to carbapenem resistance was identified, highlighting the importance of ongoing surveillance and infection control to manage the threat posed by these resistant bacteria in healthcare environments.
Article Abstract
In this study, an IncFII plasmid pIncFII-NDM5 carrying was found in carbapenem-resistant serovar Typhimurium ( serovar Typhimurium), which has conjugative transferability and carried , , ), and four resistance genes that can mediate resistance to multiple antibiotics including cephalosporins, beta-lactamase inhibitor combinations, carbapenems, and macrolides. Phylogenetic analysis showed that 1104-65 and 1104-75 were closely related to other serovar Typhimurium in this area. The above-mentioned serovar Typhimurium chromosome carries , , and ) genes, so the antibiotic resistance of isolates will be further enhanced after obtaining the pIncFII_NDM5-like plasmid. Meanwhile, we discovered a novel genetic structure of mediated by the IS composite transposon, which will expand our understanding of the emergence and spread of carbapenem-resistance genes. Altogether, the presence of the IncFII plasmid pIncFII-NDM5 further underscores the need for vigilant surveillance and appropriate infection control measures to mitigate the impact of carbapenem-resistant serovar Typhimurium in clinical settings.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10732066 | PMC |
| http://dx.doi.org/10.1128/msphere.00480-23 | DOI Listing |
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