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http://dx.doi.org/10.3389/fphys.2023.1304715 | DOI Listing |
Front Immunol
January 2025
Centre of Experimental Medicine and Surgery, Institute of Medical Sciences, Banaras Hindu University, Varanasi, India.
Understanding the development and maintenance of immunological memory is important for efforts to eliminate parasitic diseases like leishmaniasis. Leishmaniasis encompasses a range of pathologies, resulting from infection with protozoan parasites belonging to the subgenera and of the genus A striking feature of these infections is that natural or drug-mediated cure of infection generally confers life-long protection against disease. The generation of protective T cell responses are necessary to control infections.
View Article and Find Full Text PDFEur J Neurosci
January 2025
Pharmacology and Neurobiology Laboratory of the Immunophysiology and Pharmacology Department, School of Medicine and Biomedical Sciences (ICBAS), University of Porto, Porto, Portugal.
Animal models have been crucial for scientific development, allowing researchers to understand the underlying mechanisms of various human conditions, and are far from becoming obsolete in scientific research. However, the ethics of animal experimentation has been a prevalent question between both experts and nonexperts. This essay tackles the advantages and disadvantages of the usage of animal models while delving into new alternatives that have emerged in light of contemporary science.
View Article and Find Full Text PDFDrug Saf
January 2025
International Society of Pharmacovigilance, Middle East Chapter, Dubai, UAE.
J Equine Vet Sci
January 2025
Equine Physiology, Department of Animal Science, College of Agriculture and Life Sciences, Kleberg 249D; Department of Kinesiology & Sport Management, School of Education and Human Development, Gilchrist 309, Texas A&M University, 2471 TAMU | College Station, TX 77843-2471.
Eur J Neurosci
January 2025
Department of Biology, Concordia University, Montreal, QC, Canada.
Through the lens of preclinical research on substance use disorders (SUD), I propose a reflection aimed at re-evaluating animal models in neuroscience, with a focus on ecological relevance. While rodent models have provided valuable insights into the neurobiology of SUD, the field currently faces a validation crisis, with findings often failing to translate into effective human treatments. Originally designed to address the lack of reproducibility in animal studies, the current global gold standard of rigorous standardization has led to increasingly controlled environments.
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