The objective of this project was to improve communication, patient throughput, and rounding efficiency. Primary outcome studied was transfer/discharge order entry time and secondary outcomes included medication order entry time, staff perception, and time spent per patient. The location was a level one pediatric intensive care unit in an academic children's hospital. Utilizing Lean Six methodologies the major contributor to increased variability was different attending physician rounding patterns. These patterns were evaluated by a multidisciplinary committee, and the most efficient was adopted by all attending physicians during the study period. Data was collected by secret observers and a pre-post staff perception survey. Transfer/discharge order entry improved by 45 minutes/patient. Medication order entry improved by 89 minutes/order. Staff survey showed increased satisfaction in 9 of 12 aspects. Time spent per patient increased by 20%. In conclusion, standardization of rounds improved patient throughput, medication order entry, and staff satisfaction while increasing value-added time during rounds.
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http://dx.doi.org/10.1097/JMQ.0000000000000156 | DOI Listing |
Pathogens
December 2024
Unidad de Investigación Biomédica de Zacatecas, Instituto Mexicano del Seguro Social, Zacatecas 98000, Mexico.
The development of antivirals for respiratory viruses has advanced markedly in response to the growing threat of pathogens such as Influenzavirus (IAV), respiratory syncytial virus (RSV), and SARS-CoV-2. This article reviews the advances and challenges in this field, highlighting therapeutic strategies that target critical stages of the viral replication cycle, including inhibitors of viral entry, replication, and assembly. In addition, innovative approaches such as inhibiting host cellular proteins to reduce viral resistance and repurposing existing drugs are explored, using advanced bioinformatics tools that optimize the identification of antiviral candidates.
View Article and Find Full Text PDFMetabolites
December 2024
Department of Data Science and Knowledge Discovery, Simula Metropolitan Center for Digital Engineering, 0130 Oslo, Norway.
: Metabolomics measurements are noisy, often characterized by a small sample size and missing entries. While data-driven methods have shown promise in terms of analyzing metabolomics data, e.g.
View Article and Find Full Text PDFRev Med Suisse
January 2025
Unité des dépendances, Service de médecine de premier recours, Hôpitaux universitaires de Genève, 1211 Genève 14.
The use of psychoactive substances affects more men than women, with a prevalence that is 1.3 to 2 times higher, except for the use of sedatives. Men are also more affected by accidents, injuries, and acts of violence.
View Article and Find Full Text PDFSci Rep
January 2025
College of Mining, Guizhou University, Guiyang, 550025, Guizhou, China.
In order to solve the problems of serious deformation and difficult support of roadway surrounding rock in the process of gob-side entry driving, taking 230,708 working face of Huopu Mine as the engineering background, the migration characteristics of overburden rock and the stress distribution of surrounding rock before and after roof cutting in the process of gob-side entry driving were studied by means of theoretical analysis, similar simulation test and field measurement. The results show that: ① the establishment of lateral suspension mechanical model analysis found that, with the increase of coal seam dip angle, the reduction of the coal pillar bearing capacity before and after cutting the top gradually decreases, the dip angle of coal seam is 30°, Compared with the reduction of coal pillar bearing capacity before roof cutting is 2164 KN; with the increase of the overburden rock caving angle, the reduction of the coal pillar bearing capacity before and after cutting the top increases continuously, the caving angle of overburden rock is 63°, Compared with the reduction of coal pillar bearing capacity before roof cutting is 2218 KN. ② After the implementation of roof cutting and cutting off the overhanging roof structure, the stress of the surrounding rock of the coal pillar gang in the roadway has significantly decreased by 18.
View Article and Find Full Text PDFJ Adolesc Health
January 2025
STAD, Stockholm Prevents Alcohol and Drug Problems, Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet, & Stockholm Health Care Services, Region Stockholm, Stockholm, Sweden.
Purpose: In 1996, a multicomponent alcohol prevention intervention was launched and later institutionalized in Stockholm. This study examines the long-term effects of the program on compliance with the legal minimum age limit for alcohol service at licensed premises.
Methods: The intervention comprised community mobilization and collaboration, training, and enforcement aimed at preventing alcohol service to underage (<18 years) or obviously intoxicated patrons.
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