AI Article Synopsis
- A study in Sierra Leone aimed to assess the incidence of catheter-associated urinary tract infections (CAUTI) and antibiotic resistance in two hospitals, highlighting a significant knowledge gap due to a lack of surveillance.
- Among 459 patients, 14.8% of catheterized individuals developed CAUTI, with E. coli and Klebsiella being the most prevalent bacteria isolated.
- The study found high antibiotic resistance rates for certain bacteria, underscoring the need for improved microbiology diagnostics and better catheter care practices to combat CAUTI and multi-drug resistant organisms.
Article Abstract
Objective: Catheter-associated urinary tract infections (CAUTI) are common worldwide, but due to limited resources, its actual burden in low-income countries is unknown. Currently, there are gaps in knowledge about CAUTI due to lack of surveillance activities in Sierra Leone. In this prospective cohort study, we aimed to determine the incidence of CAUTI and associated antibiotic resistance in two tertiary hospitals in different regions of Sierra Leone.
Results: The mean age of the 459 recruited patients was 48.8 years. The majority were females (236, 51.3%). Amongst the 196 (42.6%) catheterized patients, 29 (14.8%) developed CAUTI. Bacterial growth was reported in 32 (84%) patients. Escherichia coli (14, 23.7%), Klebsiella pneumoniae (10, 17.0%), and Klebsiella oxytoca (8, 13.6%) were the most common isolates. Most isolates were ESBL-producing Enterobacteriaceae (33, 56%) and WHO Priority 1 (Critical) pathogens (38, 71%). Resistance of K. pneumoniae, K. oxytoca, E. coli, and Proteus mirabilis was higher with the third-generation cephalosporins and penicillins but lower with carbapenems, piperacillin-tazobactam and amikacin. To reduce the high incidence of CAUTI and multi-drug resistance organisms, urgent action is needed to strengthen the microbiology diagnostic services and develop and implement catheter bundles that provide clear guidance for catheter insertion, care and removal.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10619308 | PMC |
| http://dx.doi.org/10.1186/s13104-023-06591-w | DOI Listing |
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