AI Article Synopsis
- Follicular helper T cells (Tfh) are crucial for B cell selection and clonal expansion in germinal centers (GCs), while follicular regulatory T cells (Tfr) prevent self-reactive B cells and help to resolve immune responses.
- Research shows that GCs continuously recruit T cells from both naïve conventional and thymic regulatory T cell populations.
- The fate of these T cells in GCs depends on their timing of recruitment, with new arrivals developing into Tfh cells during early GC phases, and Tfr cells emerging during contraction phases, influenced by antigen availability and vaccination methods.
Article Abstract
Follicular helper T cells (T) mediate B cell selection and clonal expansion in germinal centers (GCs), and follicular regulatory T cells (T) prevent the emergence of self-reactive B cells and help to extinguish the reaction. Here we show that GC reactions continually recruit T cells from both the naïve conventional and naive thymic regulatory T cell (Treg) repertoires. In the early GC, newly recruited T cells develop into T, whereas cells entering during the contraction phase develop into T cells that contribute to GC dissolution. The T fate decision is associated with decreased antigen availability and is modulated by slow antigen delivery or mRNA vaccination. Thus, invasion of ongoing GCs by newly developing T and T helps remodel the GC based on antigen availability.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10618265 | PMC |
| http://dx.doi.org/10.1038/s41467-023-41880-9 | DOI Listing |
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